オオモト　マサノリ
  大本　まさのり
   所属   薬学部 薬学科
   職種   教授
言語種別 英語
発行・発表の年月 2014/12
形態種別 学術論文
査読 査読あり
標題 Genetic Influence of Dopamine Receptor, Dopamine Transporter, and Nicotine Metabolism on Smoking Cessation and Nicotine Dependence in a Japanese Population
執筆形態 共著
掲載誌名 BMC Genetics
出版社・発行元 BioMed Central
巻・号・頁 15(151)
著者・共著者 Masanori Ohmoto, Tatsuo Takahashi, Yoko Kubota, Shinjiro Kobayashi, and Yasuhide Mitsumoto
概要 This study investigated whether polymorphisms of the ankyrin repeat and kinase domain containing 1 gene (ANKK1), which is adjacent to the dopamine D2 receptor gene (DRD2), and the dopamine transporter (SLC6A3) and cytochrome P450 2A6 (CYP2A6) genes influence smoking cessation and nicotine dependence in a Japanese population. Genotyping results suggested that nicotine dependence among current smokers homozygous for the SLC6A3 10r allele was lower than that of smokers carrying the minor alleles, and that the CYP2A6 polymorphism might mediate this association. Furthermore, the age at which current smokers began smoking might moderate the association between their genetic polymorphisms and nicotine dependence.