教員情報 - 林　秀行 | 千里金蘭大学

学歴

職歴

著書・論文歴

所属学会

受賞学術賞

委員会・協会等

（最終更新日：2024-04-10 10:52:17）

  ハヤシ　ヒデユキ   HAYASHI Hideyuki
  林　秀行
   所属   千里金蘭大学看護学部看護学科

職種教授

■ 学歴

1.	1982/04～1986/03	大阪大学大学院医学研究科生理系専攻博士課程修了医学博士　甲第03362号
2.	1976/04～1982/03	大阪大学医学部医学科卒業

■ 職歴

1.	2023/03	大阪医科薬科大学名誉教授
2.	2021/04	大阪医科薬科大学教授
3.	2012/04～2021/03	大阪医科大学教授
4.	2004/04～2012/03	大阪医科大学教授
5.	1994/02～2004/03	大阪医科大学助教授
6.	1988/02～1994/02	大阪医科大学講師
7.	1987/04～1988/02	大阪大学医学部薬理学第二講座助手
8.	1986/04～1987/03	日本学術振興会特別研究員
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■ 著書・論文歴

1.	著書	タンパク質科学 : 構造・物性・機能（共著） 2005/10
2.	著書	タンパク質の分子設計（共著） 2001/02
3.	著書	タンパク質―科学と工学（共著） 1999/06
4.	論文	Estimation of the true infection rate and infection fatality rate of coronavirus disease 2019 in each country. J. Infect. Public Health 15(2),210-213頁（共著） 2022/02
5.	論文	Microcrystal preparation for serial femtosecond X-ray crystallography of bacterial copper amine oxidase. Acta Crystallogr. Sect. F 77(10),356-363頁（共著） 2021/10
6.	論文	Correlation between polymerase chain reaction (PCR) examination rate among the population and the containment of the COVID-19 pandemic. Public Health 191,31-32頁（共著） 2021/02
7.	論文	Reaction of threonine synthase with the substrate analogue 2-amino-5-phosphonopentanoate: Implications into the proton transfer at the active site. J. Biochem. 167(4),357-364頁（共著） 2020/11
8.	論文	Unique protonation states of aspartate and topaquinone in the active site of copper amine oxidase. RSC Adv. 10(63),38631-38639頁（共著） 2020/10
9.	論文	Neutron crystallography of copper amine oxidase reveals keto/enolate interconversion of the quinone cofactor and unusual proton sharing. Proc. Natl. Acad. Sci. U. S. A. 117(20),10818-10824頁（共著） 2020/05
10.	論文	Identification of O-acetylhomo- serine sulfhydrylase, a putative enzyme responsible for methionine biosynthesis in Clostridioides difficile: Gene cloning and biochemical characterizations. IUBMB Life. 71(11),1815-1823頁（共著） 2019/07
11.	論文	In crystallo thermodynamic analysis of conformational change of the topaquinone cofactor in bacterial copper amine oxidase. Proc. Natl. Acad. Sci. U. S. A. 116(1),135-140頁（共著） 2019/01
12.	論文	Molecular mechanism of the reaction specificity in threonine synthase: Importance of the substrate conformations. J. Phys. Chem. B. 121(22),5536-5543頁（共著） 2017/06
13.	論文	Role of the Tyr270 residue in 2-methyl-3-hydroxypyridine-5- carboxylic acid oxygenase from Mesorhizobium loti. J. Biosci. Bioeng. 123(2),154-162頁（共著） 2017/02
14.	論文	Probing the catalytic mechanism of copper amine oxidase from Arthrobacter globiformis with halide ions. J. Biol. Chem. 290(38),23094-23109頁（共著） 2015/09
15.	論文	Cloning and characterization of a novel fold-type I branched-　chain amino acid aminotransferase from the hyperthermophilic archaeon Thermococcus sp. CKU-1. Extremophiles 18(3),589-602頁（共著） 2014/05
16.	論文	Down-regulation of collagen I biosynthesis in intestinal epithelial cells exposed to indomethacin: a comparative proteome analysis. J. Proteomics. 103,35-46頁（共著） 2014/05
17.	論文	A QM/MM study of the L-threonine formation reaction of threonine synthase: Implications into the mechanism of the reaction specificity. J. Am. Chem. Soc. 136(12),4525-4533頁（共著） 2014/03
18.	論文	High-resolution crystal structure of copper amine oxidase from Arthrobacter globiformis: assignment of bound diatomic molecules as O2. Acta Crystallogr. D. Biol. Crystallogr. 69(12),2483-2494頁（共著） 2013/12
19.	論文	Boundary of the nucleotide- binding domain of Streptococcus ComA based on functional and structural analysis. Biochemistry 52(15),2545-2555頁（共著） 2013/04
20.	論文	Arabidopsis molybdopterin biosynthesis protein Cnx5 collaborates with the ubiquitin-like protein Urm11 in the thio-modifica- tion of tRNA. J. Biol. Chem. 287(36),30874-30884頁（共著） 2012/08
21.	論文	Structural insights into the substrate specificity of bacterial copper amine oxidase obtained by using irreversible inhibitors. J. Biochem. 151(2),167-178頁（共著） 2012/02
22.	論文	Role of a conserved arginine residue during catalysis in serine palmitoyltransferase. FEBS Lett. 585(12),1729-1734頁（共著） 2011/06
23.	論文	Analysis of mammalian histidine decarboxylase dimerization interface reveals an electrostatic hotspot important for catalytic site topology and function. J. Chem. Theory Comput. 7(6),1935-1942頁（共著） 2011/05
24.	論文	Product-assisted catalysis as the basis of the reaction specificity of threonine synthase. J. Biol. Chem. 286(4),2774-2784頁（共著） 2011/01
25.	論文	Crystal structure of the peptidase domain of Streptococcus ComA, a bifunctional ATP-binding cassette transporter involved in the quorum-sensing pathway. J. Biol. Chem. 285(14),10777-85頁（共著） 2010/04
26.	論文	Reaction mechanism and molecular basis for selenium/sulfur discrimination of selenocysteine lyase. J. Biol. Chem. 285(16),12133-12139頁（共著） 2010/04
27.	論文	Structural insights into the enzymatic mechanism of serine palmitoyltransferase from Sphingobacterium multivorum. J. Biochem. 146(4),549-562頁（共著） 2009/10
28.	論文	Multifunctional role of His159 in the catalytic reaction of serine palmitoyltransferase. J. Biol. Chem. 284(23),15487-15495頁（共著） 2009/06
29.	論文	Thio-modification of yeast cytosolic tRNA requires a ubiquitin-related system that resembles bacterial sulfur transfer systems. J. Biol. Chem. 283(41),27469-27476頁（共著） 2008/10
30.	論文	Further insight into the mechanism of stereoselective proton abstraction by bacterial copper amine oxidase. Biochemistry 47(29),7726-7733頁（共著） 2008/07
31.	論文	Acceleration of the substrate Cα deprotonation by an analogue of the second substrate palmitoyl-CoA in serine palmitoyl- transferase. J. Biol. Chem. 283,7542-7553頁（共著） 2008/03
32.	論文	Substrate recognition mechanism of the peptidase domain of the quorum-sensing-signal-pro- ducing ABC transporter ComA from Streptococcus. Biochemistry 47(8),2531-2538頁（共著） 2008/02
33.	論文	Crystal structure of pyridoxamine–pyruvate aminotransferase from Mesorhizobium loti MAFF303099. J. Biol. Chem. 283,1120-7頁（共著） 2008/01
34.	論文	Molecular characterization of membrane-associated soluble serine palmitoyltransferases from Sphingobacterium multivorum and Bdellovibrio stolpii. J. Bacteriol. 189(15),5749-5761頁（共著） 2007/08
35.	論文	Thio modification of yeast cytosolic tRNA is an iron-sulfur protein-dependent pathway. Mol. Cell. Biol. 27(8),2841-2847頁（共著） 2007/04
36.	論文	Gallate, the component of HIF-inducing catechins, inhibits HIF prolyl hydroxylase. Biochem. Biophys. Res. Commun. 351(1),234-239頁（共著） 2006/12
37.	論文	Crystal structures of nonoxidative zinc-dependent 2,6-dihy- droxybenzoate (γ-resorcylate) decarboxylase from Rhizobium sp. strain MTP-10005. J. Biol. Chem. 281(45),34365-34373頁（共著） 2006/11
38.	論文	Molecular cloning, expression and characterization of pyridoxamine–pyruvate aminotrans- ferase. Biochem. J. 396(3),499-507頁（共著） 2006/06
39.	論文	Kinetic and structural studies on the catalytic role of the aspartic acid residue conserved in copper amine oxidase. Biochemistry 45(13),4105-4120頁（共著） 2006/04
40.	論文	Quantum mechanical hydrogen tunneling in bacterial copper amine oxidase reaction. Biochem. Biophys. Res. Commun. 342(2),414-423頁（共著） 2006/04
41.	論文	Expression and characterization of the peptidase domain of Streptococcus pneumoniae ComA, a bifunctional ATP-bind- ing cassette transporter involved in quorum sensing pathway. J. Biol. Chem. 281(8),4726-4731頁（共著） 2006/02
42.	論文	Binding of C5-dicarboxylic substrate to aspartate aminotransferase: implications for the conformational change at the transaldimination step. Biochemistry 44(23),8218-8229頁（共著） 2005/06
43.	論文	Crystal structure of a putative aspartate aminotransferase belonging to subgroup IV. Proteins 55,487-92頁（共著） 2004/05
44.	論文	Crystal structures of glutamine:phenylpyruvate amino- transferase from Thermus thermophilus HB8: induced fit and substrate recognition. J. Biol. Chem. 279(16),16518-16525頁（共著） 2004/04
45.	論文	Yeast Nfs1p is involved in thio-modification of both mitochondrial and cytoplasmic tRNAs. J. Biol. Chem. 279(13),12363-12368頁（共著） 2004/03
46.	論文	Reactions of serine palmitoyltransferase with serine and molecular mechanisms of the actions of serine derivatives as inhibitors. Biochemistry 43(4),1082-1092頁（共著） 2004/02
47.	論文	Instability of the apo form of aromatic L-amino acid decarboxylase in vivo and in vitro: implications for the involvement of the flexible loop that covers the active site. J. Biochem. 135(1),33-42頁（共著） 2004/01
48.	論文	Glutamine:phenylpyruvate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus HB8. J. Biochem. 134(6),843-851頁（共著） 2003/12
49.	論文	Crystal structures of threonine synthase from Thermus thermophilus HB8: conformational change, substrate recognition, and mechanism. J. Biol. Chem. 278(46),46035-46045頁（共著） 2003/11
50.	論文	Reaction of aspartate aminotransferase with C5-dicarbox- ylic acids: comparison with the reaction with C4-dicarboxylic acids. J. Biochem. 134(2),277-285頁（共著） 2003/08
51.	論文	Characterization of histidinol phosphate aminotransferase from Escherichia coli. Biochim. Biophys. Acta. 1647(1-2.),321-324頁（共著） 2003/04
52.	論文	Crystal structures of branched- chain amino acid aminotransferase complexed with glutamate and glutarate: true reaction intermediate and double substrate recognition of the enzyme. Biochemistry 42(13),3725-3733頁（共著） 2003/04
53.	論文	Conformational change in aspartate aminotransferase on substrate binding induces strain in the catalytic group and enhances catalysis. J. Biol. Chem. 278(11),9481-9488頁（共著） 2003/03
54.	論文	Structure of imidazole glycerol phosphate synthase from Thermus thermophilus HB8: open-closed conformational change and ammonia tunneling. J. Biochem. 132(5),759-765頁（共著） 2002/11
55.	論文	Spectroscopic analysis of recombinant rat histidine decarboxylase. J. Biochem. 132(3),433-439頁（共著） 2002/09
56.	論文	Reaction mechanism of alanine racemase from Bacillus stearothermophilus: X-ray crystallographic studies of the enzyme bound with N-(5′-phosphopyri- doxyl)alanine. J. Biol. Chem. 277(21),19166-19172頁（共著） 2002/05
57.	論文	Specificity analysis and mechanism of aurone synthesis catalyzed by aureusidin synthase, a polyphenol oxidase homolog responsible for flower coloration. FEBS Lett. 499(1-2.),107-111頁（共著） 2001/06
58.	論文	Structures of Escherichia coli branched-chain amino acid aminotransferase and its complexes with 4-methylvalerate and 2-methylleucine: induced fit and substrate recognition of the enzyme. Biochemistry 40(25),7453-7463頁（共著） 2001/06
59.	論文	A water-soluble homodimeric serine palmitoyltransferase from Sphingomonas paucimobilis EY2395T strain. Purification, characterization, cloning, and overproduction. J. Biol. Chem. 276(21),18249-18256頁（共著） 2001/05
60.	論文	Structures of Escherichia coli histidinol-phosphate aminotrans- ferase and its complexes with histidinol-phosphate and N-(5′- phosphopyridoxyl)-L-glutamate: double substrate recognition of the enzyme. Biochemistry 40(15),4633-4644頁（共著） 2001/04
61.	論文	Contributions of the substrate-binding arginine residues to maleate-induced closure of the active site of Escherichia coli aspartate aminotransferase. Eur. J. Biochem. 268(6),1640-1645頁（共著） 2001/03
62.	論文	Nuclear localization of yeast Nfs1p is required for cell survival. J. Biol. Chem. 276(11),8314-8320頁（共著） 2001/03
63.	論文	Strain is more important than electrostatic interaction in controlling the pK_a of the catalytic group in aspartate aminotransferase. Biochemistry 40(2),353-360頁（共著） 2001/01
64.	論文	The substrate activation process in the catalytic reaction of Escherichia coli aromatic amino acid aminotransferase. Biochemistry 39(50),15418-15428頁（共著） 2000/12
65.	論文	Acid-base chemistry of the reaction of aromatic L-amino acid decarboxylase and dopa analyzed by transient and steady-state kinetics: preferential binding of the substrate with its amino group unprotonated. Biochemistry 38(47),15615-15622頁（共著） 1999/11
66.	論文	Antibody-independent classical complement pathway activation and homologous C3 deposition in xeroderma pigmentosum cell lines. Clin. Exp. Immunol. 116(3),547-53頁（共著） 1999/06
67.	論文	The imine–pyridine torsion of the pyridoxal 5′-phosphate Schiff base of aspartate aminotransferase lowers its pK_a in the unliganded enzyme and is crucial for the successive increase in the pK_a during catalysis. Biochemistry 37(43),15076-15085頁（共著） 1998/10
68.	論文	Aromatic L-amino acid decarboxylase: conformational change in the flexible region around Arg334 is required during the transaldimination process. Protein Sci. 7(8),1802-1810頁（共著） 1998/08
69.	論文	cDNA cloning and characterization of mouse nifS-like protein, m-Nfs1: mitochondrial localization of eukaryotic NifS-like proteins. FEBS Lett. 433(1-2.),143-148頁（共著） 1998/08
70.	論文	Activation of protein phosphatase 2A by cAMP-dependent protein kinase-catalyzed phosphorylation of the 74-kDa B″ (δ) regulatory subunit in vitro and identification of the phosphorylation sites. FEBS Lett. 430(3),312-316頁（共著） 1998/07
71.	論文	Crystal structures of Paracoccus denitrificans aromatic amino acid aminotransferase: a substrate recognition site constructed by rearrangement of hydrogen bond network. J. Mol. Biol. 280(3),443-461頁（共著） 1998/07
72.	論文	Analysis of the pH- and ligand-induced spectral transitions of tryptophanase: activation of the coenzyme at the early steps of the catalytic cycle. Biochemistry 37(9),3043-3052頁（共著） 1998/03
73.	論文	Transient-state kinetics of the reaction of aspartate aminotransferase with aspartate at low pH reveals dual routes in the enzyme-substrate association process. Biochemistry 36(44),13558-13569頁（共著） 1997/11
74.	論文	OCAM: A new member of the neural cell adhesion molecule family related to zone-to-zone projection of olfactory and vomeronasal axons. J. Neurosci. 17(15),5830-5842頁（共著） 1997/08
75.	論文	Three-dimensional structure of Escherichia coli branched-chain amino acid aminotransferase at 2.5 Å resolution. J. Biochem. 121(4),637-641頁（共著） 1997/05
76.	論文	An anomalous side reaction of the Lys303 mutant aromatic L-amino acid decarboxylase unravels the role of the residue in catalysis. J. Biochem. 121(3),604-611頁（共著） 1997/03
77.	論文	Identification of autophosphorylation sites in c-Yes purified from rat liver plasma membranes. J. Biochem. 121(1),104-111頁（共著） 1997/01
78.	論文	Paracoccus denitrificans aromatic amino acid aminotransferase: a model enzyme for the study of dual substrate recognition mechanism. J. Biochem. 121(1),161-171頁（共著） 1997/01
79.	論文	Use of ¹H–¹⁵N heteronuclear multiple-quantum coherence NMR spectroscopy to study the active site of aspartate aminotransferase. Biochemistry 36(3),615-625頁（共著） 1997/01
80.	論文	Cloning and characterization of the tyrB gene from Salmonella typhimurium. Biochim. Biophys. Acta–Gene Struct. Expr. 1308(3),189-192頁（共著） 1996/09
81.	論文	Functionally important residues of aromatic L-amino acid decarboxylase probed by sequence alignment and site-directed mutagenesis. J. Biochem. 120(2),369-376頁（共著） 1996/08
82.	論文	Analysis of the substrate-recognition mode of aromatic amino acid aminotransferase by combined use of quasisubstrates and site-directed mutagenesis: Systematic hydroxy-group addition/deletion studies to probe the enzyme–substrate interactions. Biochemistry 35(21),6754-6761頁（共著） 1996/05
83.	論文	A large compressibility change of protein induced by a single amino acid substitution. Protein Sci. 5(3),542-545頁（共著） 1996/03
84.	論文	Molecular cloning of a 74-kDa regulatory subunit (B″ or δ) of human protein phosphatase 2A. FEBS Lett. 379(1),107-111頁（共著） 1996/01
85.	論文	Reaction of aspartate aminotransferase with L-erythro-3- hydroxyaspartate: Involvement of Tyr70 in stabilization of the catalytic intermediates. Biochemistry 34(29),9413-9423頁（共著） 1995/07
86.	論文	Purification and characterization of [³H]mepyramine (histamine H1 antagonist)-binding protein from rat liver: a highly homologous protein with cytochrome P450 2D. J. Biochem. 117(5),993-998頁（共著） 1995/05
87.	論文	NMR studies of ¹H resonances in the 10–18-ppm range for aspartate aminotransferase from Escherichia coli. J. Biol. Chem. 269(45),28027-28033頁（共著） 1994/11
88.	論文	X-ray crystallographic study of pyridoxamine 5′-phosphate-type aspartate aminotransferases from Escherichia coli in three forms. J. Biochem. 116(5),1001-1012頁（共著） 1994/11
89.	論文	Site-directed mutagenesis of the histamine H1 receptor: roles of aspartic acid-107, asparagine-198 and threonine-194. Biochem. Biophys. Res. Commun. 203(2),1096-1101頁（共著） 1994/09
90.	論文	Aspartate aminotransferase from a thermophilic formate-utilizing methanogen, Methanobacterium thermoformicicum strain SF-4: relation to serine and phosphoserine aminotransferases, but not to the aspartate aminotransferase family. J. Biochem. 115(2),309-317頁（共著） 1994/02
91.	論文	Protonation state of the active-site Schiff base of aromatic amino acid aminotransferase: modulation by binding of ligands and implications for its role in catalysis. J. Biochem. 115(1),156-161頁（共著） 1994/01
92.	論文	Escherichia coli aromatic amino acid aminotransferase: Characterization and comparison with aspartate aminotransferase. Biochemistry 32(45),12229-12239頁（共著） 1993/11
93.	論文	Rat liver aromatic L-amino acid decarboxylase: Spectroscopic and kinetic analysis of the coenzyme and reaction intermediates. Biochemistry 32(3),812-818頁（共著） 1993/01
94.	論文	Further studies on aspartate aminotransferase of thermophilic methanogens by analysis of general properties, bound cofactors, and subunit structures. J. Biochem. 112(6),811-815頁（共著） 1992/12
95.	論文	Evaluation of the holoenzyme content of aromatic L-amino acid decarboxylase in brain and liver tissues. Biochem. Biophys. Res. Commun. 186(3),1242-1248頁（共著） 1992/08
96.	論文	Replacement of an interdomain residue Val39 of Escherichia coli aspartate aminotransferase affects the catalytic competence without altering the substrate specificity of the enzyme. J. Biochem. 109(5),699-704頁（共著） 1991/05
97.	論文	Pre-steady-state kinetics of Escherichia coli aspartate aminotransferase catalyzed reactions and thermodynamic aspects of its substrate specificity. Biochemistry 29(23),5469-5476頁（共著） 1990/06
98.	論文	Effects of replacement of tryptophan-140 by phenylalanine or glycine on the function of Escherichia coli aspartate aminotransferase. Biochem. Biophys. Res. Commun. 1 167(2),407-412頁（共著） 1990/03
99.	論文	[Arg292 → Val] or [Arg292 → Leu] mutation enhances the reactivity of Escherichia coli aspartate aminotransferase with aromatic amino acids. Biochem. Biophys. Res. Commun. 159(1),337-342頁（共著） 1989/02
100.	論文	Demonstration of histaminergic neurons in horizontal cells of guinea pig retina. Brain Res. 410(2),269-274頁（共著） 1987/05
101.	論文	Affinity purification and characterization of serine hydroxymethyltransferases from rat liver. J. Biochem. 101(3),643-652頁（共著） 1987/03
102.	論文	Purification of L-dopa decarboxylase from rat liver and production of polyclonal and monoclonal antibodies against it. J. Biochem. 101(2),405-414頁（共著） 1987/02
103.	論文	Demonstration of immunohistochemical and immunochemical cross-reactivity of L-histidine and L-dopa decarboxylases using antibodies against the two enzymes. Biochem. Biophys. Res. Commun. 141(1),306-312頁（共著） 1986/11
104.	論文	Pyridoxal 5′-phosphate-depend- ent histidine decarboxylase. Inactivation by α-fluoromethyl- histidine and comparative sequences at the inhibitor- and coenzyme-binding sites. J. Biol. Chem. 261(24),11003-11009頁（共著） 1986/08
105.	論文	Histaminergic axons in the neostriatum and cerebral cortex of the rat: a correlated light and electron microscopic immunocytochemical study using histidine decarboxylase as a marker. Brain Res. 364(1),114-123頁（共著） 1986/01
106.	論文	Effects of various compounds on histidine decarboxylase activity: Active site mapping. Agents Actions 17(1),32-37頁（共著） 1985/10
107.	論文	ピリドキサールリン酸依存性ヒスチジン脱炭酸酵素の親和標識博士論文医学博士 14401甲第03362号（単著） 1985/03
108.	論文	Fine structure of histaminergic neurons in the caudal magnocellular nucleus of the rat as demonstrated by immunocytochemistry using histidine decarboxylase as a marker. J. Comp. Neurol. 229(2),233-241頁（共著） 1984/10
109.	論文	Mechanism of inactivation of mammalian L-histidine decarboxylase by (S)-α-fluoromethyl- histidine. Biochem. Pharmacol. 33(7),983-990頁（共著） 1984/04
110.	論文	Purification of histidine decarboxylase from the liver of fetal rats and its immunochemical and immunohistochemical characterization. J. Biol. Chem. 259(8),5214-5221頁（共著） 1984/04
111.	論文	Evidence for the presence of a histaminergic neuron system in the rat brain: An immunohistochemical analysis. Neurosci. Lett. 39(3),249-254頁（共著） 1983/09
112.	その他	ビタミンB₆酵素の構造と機能に関する研究ビタミン 97(1),1-12頁（単著） 2023/01
113.	その他	ピリドキサール酵素の反応機構生化学 86(4),214-231頁（単著） 2014/04
114.	その他	Esmond E. Snell —The pathfinder of B vitamins and cofactors. J. Biochem. 147(4),451-457頁（共著） 2010/04
115.	その他	酵素反応のエネルギー論生化学 74(1),5-16頁（単著） 2002/01
116.	その他	Pyridoxal enzymes: Mechanistic diversity and uniformity. J. Biochem. 118(3),463-473頁（単著） 1995/03
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