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オヤマダ マサヒト
Oyamada Masahito
小山田 正人 所属 藤女子大学 人間生活学部 食物栄養学科 職種 特任教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2013/01 |
| 形態種別 | 研究論文（学術雑誌） |
| 査読 | 査読あり |
| 標題 | Regulation of connexin expression by transcription factors and epigenetic mechanisms |
| 執筆形態 | 共著 |
| 掲載誌名 | BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES |
| 掲載区分 | 国外 |
| 出版社・発行元 | ELSEVIER SCIENCE BV |
| 巻・号・頁 | 1828(1),pp.118-133 |
| 著者・共著者 | Masahito Oyamada,Kumiko Takebe,Yumiko Oyamada |
| 概要 | Gap junctions are specialized cell-cell junctions that directly link the cytoplasm of neighboring cells. They mediate the direct transfer of metabolites and ions from one cell to another. Discoveries of human genetic disorders due to mutations in gap junction protein (connexin [Cx]) genes andexperimental data on connexin knockout mice provide direct evidence that gap junctional intercellular communication is essential for tissue functions and organ development, and that its dysfunction causes diseases. Thus far, 21 human genes and 20 mouse genes for connexins have been identified. Connexin expression can be regulated at many of the steps in the pathway from DNA to RNA to protein. In recent years, it has become clear that epigenetic processes are also essentially involved in connexin gene expression. In this review, we summarize recent knowledge on regulation of connexin expression by transcription factors and epigenetic mechanisms inc |
| DOI | 10.1016/j.bbamem.2011.12.031 |
| ISSN | 00052736 |
| PMID | 22244842 |
| PermalinkURL | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84870057902&origin=inward |