オオモト　マサノリ
  大本　まさのり
   所属   薬学部 薬学科
   職種   教授
言語種別 英語
発行・発表の年月 2019/02
形態種別 学術論文
査読 査読あり
標題 Effect of genetic polymorphism of brain-derived neurotrophic factor and serotonin transporter on smoking phenotypes: a pilot study of Japanese participants
執筆形態 共著
掲載誌名 Heliyon
掲載区分国外
出版社・発行元 Elsevier
著者・共著者 Masanori Ohmoto and Tatsuo Takahashi
概要 This study investigated whether a gene polymorphism causing a Val66Met substitution (rs6265) in brain-derived neurotrophic factor (BDNF) is associated with smoking initiation, smoking cessation, nicotine dependence and age of smoking initiation, in Japanese participants. Additionally, this study examined whether the S allele of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) is associated with the BDNF Val66Met polymorphism on smoking phenotypes. This pilot study provides preliminary findings regarding the influence of BDNF Val66Met on smoking phenotypes and the interacting effect of 5-HTTLPR on the association between BDNF Val66Met and smoking phenotypes in Japanese participants.