サトウ　ヒアキ
  佐藤　妃映
   所属   医療保健学部 医療技術学科
   職種   教授
言語種別 英語
発行・発表の年月 2017/04
形態種別 学術論文
標題 Gene expression analysis of hypersensitivity to mosquito bite, chronic active EBV infection and NK/T-lymphoma/leukemia
執筆形態 共著
掲載誌名 LEUKEMIA & LYMPHOMA
掲載区分国外
巻・号・頁 58(1),pp.2683-2694
著者・共著者 Washio K, Oka T, Abd Al-Kader Lamia,Muraoka M,Shimada A,Oda M, Sato H,Takata K, Kagami Y,Shimizu N, Y,Kato S,Kimura H, Nshizaki k, Yoshino T, Tsukahara H.
概要 In the present study, gene expression of CD16(−)CD56(+)-, EBV(+) HMB, CAEBV, NK-lymphoma, and NK-leukemia cell lines, which were established from patients, was analyzed using oligonucleotide microarrays and compared to that of CD56brightCD16dim/− NK cells from healthy donors. Principal components analysis showed that CAEBV and NK-lymphoma cells were relatively closely located, indicating that they had similar expression profiles. Unsupervised hierarchal clustering analyses of microarray data and gene ontology analysis revealed specific gene clusters and identified several candidate genes responsible for disease that can be used to discriminate each category of NK-LPD and NK-cell lymphoma/leukemia.