ミツモト　ヤスヒデ   Yasuhide Mitsumoto
  光本　泰秀
   所属   薬学部 薬学科
   職種   教授
言語種別 英語
発行・発表の年月 2004/08
形態種別 学術論文
査読 査読あり
標題 Olfactory impairment and Parkinson's disease-like symptoms observed in the common marmoset following administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
執筆形態 共著
掲載誌名 Acta Otolaryngol Suppl
掲載区分国外
巻・号・頁 (533),pp.80-84
著者・共著者 Takaki Miwa, Akihito Watanabe, Yasuhide Mitsumoto, Mitsuru Furukawa, Nanae Fukushima, Tetsuji Moriizumi
概要 Administration of MPTP caused common marmosets to enter an akinetic state within a few days and to show signs of impaired olfactory function. Biochemical study showed a decrease in dopamine levels, especially in tissue samples from the caudate nucleus and putamen. Immunohistochemical analysis revealed a lack of tyrosine hydroxylase immunoreactivity, not only in the substantia nigra, caudate nucleus and putamen but also in the olfactory tubercle.These results demonstrate that MPTP causes both PD-like symptoms and olfactory disturbance in the common marmoset. The olfactory disturbance observed in these animals may be due to the lack of dopamine in the olfactory tubercle.