ミツモト　ヤスヒデ   Yasuhide Mitsumoto
  光本　泰秀
   所属   薬学部 薬学科
   職種   教授
言語種別 英語
発行・発表の年月 2002/04
形態種別 学術論文
査読 査読あり
標題 Neurotrophic activity of honokiol on the cultures of fetal rat cortical neurons
執筆形態 共著
掲載誌名 Bioorg Med Chem Lett
掲載区分国外
巻・号・頁 12,pp.1163-1166
著者・共著者 Yoshiyasu Fukuyama, Kousuke Nakade, Yuka Minoshima, Ritsuko Yokoyama, Haifeng Zhai, Yasuhide Mitsumoto
概要 Honokiol, a main biphenyl neolignan of the traditional crude medicine, Magnoliae cortex, was found to show neurotrophic activity on the cultures of rat cortical neurons at concentration from 0.1 to 10 microM. In the cortical neurons cultured in serum-free medium supplemented with B27, honokiol could promote neurite outgrowth. In addition, the survival and growth of neurons were significantly enhanced by adding honokiol to the primary cultures in serum-free medium supplemented with N2. Its neurotrophic activity was comparable to 40 ng mL(-1) of bFGF at concentration of 10 microM.