ミツモト　ヤスヒデ   Yasuhide Mitsumoto
  光本　泰秀
   所属   薬学部 薬学科
   職種   教授
言語種別 英語
発行・発表の年月 2000/07
形態種別 学術論文
査読 査読あり
標題 Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons
執筆形態 共著
掲載誌名 Genomics
掲載区分国外
巻・号・頁 67,pp.146-152
著者・共著者 M Horie, Y Mitsumoto, H Kyushiki, N Kanemoto, A Watanabe, Y Taniguchi, N Nishino, T Okamoto, M Kondo, T Mori, K Noguchi, Y Nakamura, E i Takahashi, A Tanigami
概要 We evaluated the survival effect of TMEFF2 using primary cultured neurons from several regions of fetal rat brain following treatment with a recombinant TMEFF2 protein fragment consisting of the putative extracellular domain. TMEFF2 increased survival of neurons from the hippocampus and midbrain, but not from the cerebral cortex, indicating that the survival effects of TMEFF2 are specific to certain cell types. Recombinant TMEFF2 also promoted survival of mesencephalic dopaminergic neurons. Together, these findings suggest that TMEFF2 may be a novel survival factor for hippocampal and mesencephalic, but not for cortical, neurons.