オバタケ　キヨウコ
  大畠　京子
   所属   薬学部 薬学科
   職種   教授
言語種別 英語
発行・発表の年月 2013/11
形態種別 学術論文
査読 査読あり
標題 Glucosylceramide Mimics: Highly potent GCase inhibitors and selective pharmacological chaperones for mutations associated with types 1 and 2 Gaucher disease.
執筆形態 共著
掲載誌名 ChemMedChem.
巻・号・頁 8(11),pp.1805-1817
著者・共著者 Schönemann W., Gallienne E., Ikeda-Obatake K., Asano N., Nakagawa S., Kato A., Adachi I., Górecki M., Frelek .J, Martin O. R.
概要 A series of iminoxylitol derivatives carrying a C-linked di-O-acyl or di-O-alkyl glyceryl substituent were prepared and characterized. All of these compounds, which were designed as glucosylceramide (GlcCer) mimics, were nanomolar inhibitors of lysosomal β-glucosidase (glucocerebrosidase, GCase). Two of these pseudoglycolipids were further evaluated for their ability to enhance the activity of mutant GCase in human Gaucher cells.