オバタケ　キヨウコ
  大畠　京子
   所属   薬学部 薬学科
   職種   教授
言語種別 英語
発行・発表の年月 2014/02
形態種別 学術論文
査読 査読あり
標題 Effects of eugenol-reduced clove extract on glycogen phosphorylase b and the development of diabetes in the db/db mice.
執筆形態 共著
掲載誌名 Food Funct.
巻・号・頁 5(2),pp.214-219
著者・共著者 Sanae F., Kamiyama O., Ikeda-Obatake K., Higashi Y., Asano N., Adachi I., Kato A.
概要 We found that the 50% aqueous EtOH extract of clove (Syzygium aromaticum) had potent dose-dependent inhibitory activity toward glycogen phosphorylase b and glucagon-stimulated glucose production in primary rat hepatocytes. Among the components, eugeniin inhibited glycogen phosphorylase b and glucagon-stimulated glucose production in primary rat hepatocytes, with IC50 values of 0.14 and 4.7 micromolar, respectively. In sharp contrast, eugenol showed no significant inhibition toward glycogen phosphorylase b, even at a concentration of 400 micromolar. Eugenol-reduced clove extracts (erCE) were prepared and when fed to a db/db mouse they clearly suppressed the blood glucose and HbA1c levels.