シミズ　ヨシヒサ
  清水　慶久
   所属   医療保健学部 医療技術学科
   職種   教授
言語種別 英語
発行・発表の年月 2021/04/07
形態種別 学術論文
査読 査読あり
標題 Biological sources of variations of tartrate-resistant acid phosphatase 5b (TRACP5b) in a healthy Japanese population.
執筆形態 共著
掲載誌名 Annals of Clinical Biochemistry (ACB)
掲載区分国外
巻・号・頁 58(4),pp.358-367
総ページ数 10
担当範囲 データ解析および総括
著者・共著者 Wataru Kikuchi, Kiyoshi Ichihara, Kazuo Mori, Yoshihisa Shimizu
概要 Gender-specific profiles of age-related changes were observed for each parameter. Increased values starting from 40 years of age in females were most prominent for TRACP5b, followed by bone alkaline phosphatase and inorganic phosphate. TRACP5b in males decreased with body mass index, bone alkaline phosphatase and TRACP5b were higher in blood type-O subjects, especially in males. TRACPT5b was closely correlated with bone alkaline phosphatase, and moderately correlated with adjusted calcium and inorganic phosphate, especially in females aged ≥45 years. Reference intervals for each analyte were determined parametrically based on gender and age.
This study elucidated sources of variation of TRACP5b and related bone markers in healthy Japanese subjects and demonstrated a specific age profile for each marker. These results are of relevance for better clinical usage and interpretations of serum levels of bone markers.