オキムラ　ケイコ   Keiko Okimura
  興村　桂子
   所属   薬学部 薬学科
   職種   准教授
言語種別 英語
発行・発表の年月 2022/03
形態種別 著書
査読 査読あり
標題 Investigation of the Antimicrobial Activity, Cell Viability, and Hemolytic Activity of N-Fatty Acylated Myticalin A6 (3-23)-OH Derivatives
執筆形態 共著
掲載誌名 Peptide Science 2021, Y. Hayashi (Ed.)
掲載区分国内
出版社・発行元 The Japanese Peptide Society（商業出版）
巻・号・頁 pp.157-158
総ページ数 2
担当範囲 ペプチド合成、抗菌活性測定、Proceeding執筆
担当区分 筆頭著者,責任著者
著者・共著者 Keiko Okimura, Tatsuo Takahashi, Atsuya Sawada, Chinami Katsui, Tamako Shiratori, Risa Sugita, Sayuri Suzuki and Tohru Daikoku
概要 Myticalins are linear, cationic antimicrobial peptides which reported by Leoni et.al. in 2017. Our group reported that myticalin A6 (3-23)-OH, which consists only of X-Pro-Arg (X=Trp, Tyr, Leu, Ile) repeating sequence, shows the same level of antimicrobial activity as myticalin A6 against Staphylococcus aureus. In this study, we synthesized N-terminal fatty acylated myticalin A6 (3-23)-OH derivatives to investigate the antibacterial activity, cell viability and hemolytic activity. Octanoyl-myticalin A6 (3-23)-OH showed higher antimicrobial activities to S. aureus and E. coli than myticalin A6 (3-23)-OH and myristoyl-myticalin A6 (3-23)-OH.