オキムラ　ケイコ   Keiko Okimura
  興村　桂子
   所属   薬学部 薬学科
   職種   准教授
言語種別 英語
発行・発表の年月 2023/03
形態種別 著書
査読 査読あり
標題 Study of the Antimicrobial Activity and Cell Viability of N-Fatty Acylated or Tryptophan Substituted Myticalin A6 (3-23)-OH Derivatives
執筆形態 共著
掲載誌名 Peptide Science 2022, T. Doi, H. Konno, and K. Ohsawa (Eds.)
掲載区分国内
出版社・発行元 The Japanese Peptide Society（商業出版）
巻・号・頁 pp.115-116
総ページ数 2
担当範囲 ペプチド合成、抗菌活性測定、Proceeding執筆
担当区分 筆頭著者,責任著者
著者・共著者 Keiko Okimura, Tatsuo Takahashi, Risa Sugita, Sayuri Suzuki and Tohru Daikoku
概要 Myticalin A6 (3-23)-OH is an antimicrobial peptide with a 7-repeat sequence: (X-Pro-Arg)7, where X = Trp, Tyr, Leu, or Ile. We synthesized N-terminal fatty acylated or tryptophan-substituted myticalin A6 (3-23)-OH derivatives, aiming to increase their antibacterial activity and reduce their cytotoxicity. Derivatives in which Ile9 or Leu12 was substituted with Trp showed comparable antibacterial activity and cytotoxicity. IC50 values indicated 3-amino-4-(2-naphthyl)butyl- myticalin A6 (3-23)-OH was slightly less cytotoxic than myticalin A6 (3-23)-OH.