オオモト　マサノリ
  大本　まさのり
   所属   薬学部 薬学科
   職種   教授
言語種別 英語
発行・発表の年月 2012/09
形態種別 学術論文
査読 査読あり
標題 Effects of Moderating Factors Including Serotonin Transporter Polymorphisms on Smoking Behavior: A Systematic Review and Meta-analysis Update
執筆形態 共著
掲載誌名 Nicotine & Tobacco Research
著者・共著者 Masanori Ohmoto, Miyako Hirakoshi, and Yasuhide Mitsumoto
概要 The aim of this review was to report an update of a previous meta-analysis (by another group) of a possible relationship between serotonin transporter (5-HTTLPR) genotype and smoking behavior, and extend previous work by factoring in some demographic parameters (age, gender, and ethnicity) in a multiple regression model to examine the relationship between these demographic factors and the effect of 5-HTTLPR polymorphism on smoking behavior. A significant relationship stratified by ancestry was observed between the 5-HTTLPR genotype and smoking rate, but not between the 5-HTTLPR genotype and smoking initiation and persistence. Regression analysis detected effects of age and/or ethnicity as moderating factors on smoking initiation and persistence.