オキムラ　ケイコ   Keiko Okimura
  興村　桂子
   所属   薬学部 薬学科
   職種   准教授
言語種別 英語
発行・発表の年月 2024/08
形態種別 著書
査読 査読あり
標題 Investigation of the Antimicrobial Activity and Cell Viability of Myticalin A6 (3-23)-(Trp-Pro-Arg)n-OH Derivatives
執筆形態 共著
掲載誌名 Peptide Science 2023, H. Mukai and Y. Sohma (Eds.)
掲載区分国内
出版社・発行元 The Japanese Peptide Society
巻・号・頁 pp.113-114
総ページ数 2
担当範囲 ペプチド合成、抗菌活性測定、Proceeding執筆
担当区分 筆頭著者,責任著者
著者・共著者 Keiko Okimura, Tatsuo Takahashi, Ayaka Yamamoto, Michiyo Morimoto, Miho Kajino, Kana Kaimya and Tohru Daikoku
概要 Myticalin A6 (3-23)-OH is an antimicrobial peptide with a seven-fold repeat sequence [(X-Pro-Arg)7, (X = Trp, Tyr, Leu, or Ile)]. We synthesized myticalin A6 (3-23)-(Trp-Pro-Arg)n-OH derivatives and investigated their antimicrobial activity and effects on cell viability. Myticalin A6 (3-23)-Trp-Pro-Arg-OH showed higher activity than myticalin A6 (3-23)-OH against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The cell viability tended to decrease with increasing number of Trp-Pro-Arg repeats extended at the C-terminus of myticalin A6 (3-23)-OH.