ササキ　ヒロコ   Hiroko Sasaki
  佐々木　浩子
   所属   教育文化学部 教育学科
   職種   教授
言語種別 日本語
発行・発表の年月 2000
形態種別 学術論文
査読 査読あり
標題 Diverse Effect of tributy ltim on Apotosis in PC12 Cells
執筆形態 共著
掲載誌名 Biochemical and Biophysical Research Communications272
出版社・発行元 Idealibrary
巻・号・頁 557-562頁
著者・共著者 Osamu Yamanoshita, Masaaki Kurasaki, Takedhi Saito, Kyoko Takahashi, Hiroko Sasaki, Toshiyuki Hosokawa, Masashi Okabe, Jyunko Mochida, and toshio Iwakuma
概要 It has not been fully elucidated how endocrinedisrupting chemicals disrupt hormone functions or how strong their effects are compared with natural hormones. There is little information concerning the effects of tributyltin(TBT), one of the endocrine disrupters on living organisms. Although TBT at high concentration induced apoptosis in PC12 cells, TBT at low concentration inhibited the DNA fragmentation in the cells cultured in serum-free medium or in medium containing 6-hydroxydopamine. The cell viability grown in both medium conditions increased after treatment with TBT. These findings suggest that TBT exerted a apoptosis-inducing and –inhibiting effect. These diverse effect of TBT on apoptosis would cause serious damages on cell fifferentiation.