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ヤマグチ ルイ
Rui Yamaguchi
山口 類 所属 熊本保健科学大学 保健科学部 医学検査学科 熊本保健科学大学大学院 保健科学研究科 保健科学専攻 職位 准教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2019/04 |
| 形態種別 | 研究論文（学術雑誌） |
| 査読 | 査読あり |
| 標題 | Essential Role of GM-CSF-Dependent Macrophages in Human Autoimmune and Inflammatory Responses |
| 執筆形態 | 共著 |
| 掲載誌名 | J Cytokine Biol |
| 掲載区分 | 国外 |
| 巻・号・頁 | 4(1) |
| 総ページ数 | 13 |
| 担当区分 | 筆頭著者 |
| 著者・共著者 | Rui Yamaguchi, Arisa Sakamoto, Reona Yamaguchi, Misa Haraguchi, Shinji Narahara, Hiroyuki Sugiuchi and Yasuo Yamaguchi |
| 概要 | Macrophages are important cells in the innate immune system that express toll-like receptors, produce various cytokines, and have a major role in both inflammation and autoimmune diseases. These cells undergo differentiation into GM-CSF-dependent or M-CSF-dependent macrophages in response to influences in the microenvironment. Because there are marked physiological and immunological differences between mice and humans, the inflammatory response of human macrophages is not accurately reproduced by murine models. GM-CSF and M-CSF are factors that promote the differentiation of bone marrow progenitor cells and induce various changes of human macrophage lineages. |