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ハラグチ ミサ
Misa Haraguchi
原口 実紗 所属 熊本保健科学大学 保健科学部 医学検査学科 職位 講師 |
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| 言語種別 | 日本語 |
| 発行・発表の年月 | 2020/10 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | TRIM28/TIF1β and Fli-1 negatively regulate peroxynitrite generation via DUOX2 to decrease the shedding of membrane-bound fractalkine in human macrophages after exposure to substance P |
| 執筆形態 | 共著 |
| 掲載誌名 | Cytokine |
| 掲載区分 | 国外 |
| 担当範囲 | 本人担当部分：共同研究により抽出不可 |
| 著者・共著者 | Yamaguchi R, Sakamoto A, Yamaguchi R, Haraguchi M, Narahara S, Sugiuchi H,Yamaguchi Y |
| 概要 | The chemokine fractalkine is synthesized as a membrane-bound protein, but studies have shown that serum levels of soluble fractalkine are elevated in inflammatory and autoimmune diseases. Patients with autoimmune diseases also have increased serum levels of neuropeptide substance P (SP). The shedding activity of the ADAM family is induced by peroxynitrite, but that of SP is unclear. Treatment of human macrophages with SP upregulated levels of membrane-bound fractalkine. Interestingly, small interfering RNA (siRNA) for DUOX2 further increased membrane-bound fractalkine but decreased soluble fractalkine compared with cells treated with SP alone. |