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ヒルタ オサム
Osamu HIRUTA
蛭田 修 所属 熊本保健科学大学 品質保証・精度管理学共同研究講座 熊本保健科学大学大学院 保健科学研究科 保健科学専攻 職位 特命教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 1991/06 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Accumulation of Bialaphos Intermediates under High Oxygen Partial Pressure and Their Conversion to Bialaphos : Studies on the Production of Bialaphos(IV). |
| 執筆形態 | 共著 |
| 掲載誌名 | Journal of fermentation and bioengineering |
| 掲載区分 | 国内 |
| 出版社・発行元 | Society for Biotechnology, Japan |
| 巻・号・頁 | 71(6),pp.433-435 |
| 著者・共著者 | Hidehi Takebe, Osamu Hiruta, Mihoko Matsunaga, Atsuyuki Satoh, Hideo Tanaka. |
| 概要 | In bialaphos fermentation by Streptomyces hygroscopicus, production of bialaphos was reduced when the partial pressure of oxygen was increased. The culture filtrate was analyzed revealing that two possible biosynthetic intermediates of bialaphos were accumulated. These two compounds were identified to be C-P compounds having an amino group, one as a demethyl derivative of bialaphos (MP-102) and the other a demethyl derivative of AMPB [dealaninated bialaphos] (MP-101). It was also demonstrated that these demethyl derivatives were converted to bialaphos under low oxygen partial pressure, whereas the conversion was suppressed under high oxygen partial pressure. As a conclusion, methylation at the final step of the biosynthetic process of bialaphos did not proceed under high oxygen partial pressure, resulting in a low bialaphos concentration due to the accumulation of the demethyl derivatives. |