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ヨコヤマ トシロウ
TOSHIRO YOKOYAMA
横山 俊朗 所属 熊本保健科学大学 保健科学部 医学検査学科 職位 教授 |
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| 言語種別 | 日本語 |
| 発行・発表の年月 | 2010/05/05 |
| 形態種別 | 研究論文（学術雑誌） |
| 査読 | 査読あり |
| 標題 | Characteristic morphology of invasive micropapillary carcinoma of the breast: an immunohistochemical analysis. |
| 執筆形態 | 共著 |
| 掲載誌名 | Jpn J Clin Oncol. Aug; |
| 掲載区分 | 国内 |
| 巻・号・頁 | 40(8),781-787頁 |
| 著者・共著者 | Rin Yamaguchi 1, Maki Tanaka, Keiko Kondo, Toshiro Yokoyama, Yuko Kaneko, Miki Yamaguchi, Yutaka Ogata, Osamu Nakashima, Masayoshi Kage, Hirohisa Yano |
| 概要 | Invasive micropapillary carcinoma of the breast is a distinct variant of breast cancer. In the present study, we analyzed potential immunophenotypic changes in invasive micropapillary carcinoma.
Methods: Specimens from 15 patients with invasive micropapillary carcinoma were analyzed using clinicopathological and immunohistochemical methods. We also examined the relationship between clinicopathological factors using the Ki-67 labeling index. Nuclear expression of p63, involucrin and 34betaE12 were detected indicating squamous differentiation. Cytoplasmic p63 expression was also identified. The fact that the Ki-67 labeling index was significantly higher in such cases may have been associated with the aggressive behavior of these tumors. Our findings suggest that the characteristic morphology of invasive micropapillary carcinomas may be due to immunophenotypical and oncogenic changes. |