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サカイ ジュンイチ
Sakai Junichi
酒井 淳一 所属 スポーツ健康学部 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2021/01 |
| 形態種別 | 研究論文（学術雑誌） |
| 標題 | Effects of Abietane diterpenes from Rosmarinus officinalis on guinea pig hearts |
| 執筆形態 | 共著 |
| 掲載誌名 | 名古屋学院大学論集 人文・自然科学篇 |
| 掲載区分 | 国内 |
| 巻・号・頁 | 第57巻(第2号),pp.29-35 |
| 著者・共著者 | 青柳裕、一幸生、竹谷孝一、酒井淳一、堀田芳弘 |
| 概要 | A plant in the Lamiaceae family, rosemary ( Rosmarinus officinalis ) is a perennial shrub native to the Mediterranean region. The current study used right atrial specimens from guinea pigs to assess the biological activity of 3 catechol diterpenes with an abietane skeleton―carnosic acid (CA ― 1), demethylsalvicanol (DS ― 1), and carnosol (CN ― 1)―contained in rosemary. Administration of CA ― 1 had a positive inotropic effect (PIE) while administration of CN ― 1 conversely had a negative inotropic effect (NIE). Administration of DS ― 1 resulted in no changes in myocardial contractility. Administration of CA ― 1 or DS ― 1 did not result in significant changes in heart rate. However, administration of CN ― 1 had a negative chronotropic effect (NCE), and administration of CN ― 1 at a final concentration of 10 － 4 M caused cardiac arrest. In addition, the PIE of CA ― 1 was inhibited by prior administration of the phosphodiesterase (PDE) inhibitor IBMX (5 μM). |