|
ナカネ リョウ
Ryou NAKANE
中根 亮 所属 東京医療学院大学 保健医療学部 リハビリテーション学科 基礎教員 職種 助教 |
|
| 言語種別 | 英語 |
| 発行・発表の年月 | 2010/03 |
| 形態種別 | 研究論文（学術雑誌） |
| 査読 | 査読あり |
| 標題 | Excitatory action of GABA in the terminal nerve gonadotropin-releasing hormone neurons. |
| 執筆形態 | 共著 |
| 掲載誌名 | The Journal of Neurophysiology |
| 掲載区分 | 国外 |
| 巻・号・頁 | 103(3),pp.1375-84 |
| 著者・共著者 | 共著者：Ryo Nakane, Yoshitaka Oka |
| 概要 | The hypothalamic gonadotropin-releasing hormone (GnRH) neurons produce the central output regulating reproduction. In clear contrast, the terminal nerve (TN)-GnRH neurons have been suggested to function as a neuromodulatory system that regulates the motivational state of the animal. However, our knowledge about the functions of TN-GnRH neurons is still limited at present. The analysis of the neural inputs to TN-GnRH neurons which alter their pacemaker activity is the key to understanding their functions. Here we examined the GABA(A) receptor-mediated responses in the TN-GnRH neurons of adult teleost fish, the dwarf gourami, by means of gramicidin-perforated and cell-attached patch-clamp recordings. GABA(A) receptor activation depolarized TN-GnRH neurons and had excitatory effect on their electrical activity, which is contrary to most neurons in the adult brain. To elucidate the physiological functions of excitatory GABAergic inputs to TN-GnRH neurons is the next step. |