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ナカネ リョウ
Ryou NAKANE
中根 亮 所属 東京医療学院大学 保健医療学部 リハビリテーション学科 基礎教員 職種 助教 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2010/03 |
| 形態種別 | 学位論文（博士） |
| 査読 | 査読あり |
| 標題 | Physiological studies on the neural inputs to neuromodulatory GnRH peptidergic neurons |
| 執筆形態 | 単著 |
| 掲載区分 | 国内 |
| 出版社・発行元 | 東京大学 |
| 概要 | The terminal nerve (TN)-GnRH neurons have been suggested to function as a neuromodulatory system that regulates the motivational and arousal state of the animal. The analysis of the neural inputs to TN-GnRH neurons which alter their pacemaker activity is important to understand their functions. I showed that the GABA(A) receptor-mediated responses are excitatory to the pacemaker activity of the TN-GnRH neurons in the adult dwarf gourami, which is contrary to most neurons in the adult brain. Also I found that FMRFamide/NPFF, a putative cotransmitter of TN-GnRH neurons, has inhibitory effect on the pacemaker activity of TN-GnRH neurons. These results suggest that both glutamate and GABA may mediate the excitatory inputs and that the intense activation of these inputs may induce the somatodendritic release of GnRH (excitatory) and FMRFamide-like peptide (inhibitory), which are suggested to differentially regulate the pacemaker activity of TN-GnRH neurons. |