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ナカネ リョウ
Ryou NAKANE
中根 亮 所属 東京医療学院大学 保健医療学部 リハビリテーション学科 基礎教員 職種 助教 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2010/12 |
| 形態種別 | 研究論文（学術雑誌） |
| 査読 | 査読あり |
| 標題 | Electrophysiological analysis of the inhibitory effects of FMRFamide-like peptides on the pacemaker activity of gonadotropin-releasing hormone neurons |
| 執筆形態 | 共著 |
| 掲載誌名 | The Journal of Neurophysiology |
| 掲載区分 | 国外 |
| 巻・号・頁 | 104(6),pp.3518-29 |
| 著者・共著者 | 共著者：Takeshi H Saito*, Ryo Nakane*, Yasuhisa Akazome, Hideki Abe, Yoshitaka Oka
* T. H. Saito と R. Nakaneの本論文に対する貢献は同等。 |
| 概要 | The terminal nerve (TN)-GnRH neurons have been suggested to function as a neuromodulatory system that regulates the motivational state of the animal. It has been reported that the TN-GnRH neurons are immunoreactive to FMRFamide (molluscan cardioexcitatory tetrapeptide) in various amimal species. Recently, it has been suggested that the molecular identity of the FMRF-like peptide in TN-GnRH neurons is NPFF, a kind of RFamides. Here, we performed the electrophysiological experiments to examine the effects of FMRFamide/NPFF on the pacemaker activity of TN-GnRH neurons. The pacemaker activity was inhibited by FMRFamide/NPFF and this inhibition was blocked by RF9, a potent and selective antagonist for mammalian NPFF receptors. Because TN-GnRH neurons make tight cell clusters in the brain, it is possible that FMRFamide-like peptides released from TN-GnRH neurons negatively regulates the activities of their own (autocrine) and/or neighboring neurons (paracrine). |